FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

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What role do binders play in tablet formulation?

Enhance drug absorption
Increase drug stability
Provide stability and strength to the tablet
Act as a disintegrant

The correct answer is: Provide stability and strength to the tablet

In tablet formulation, binders serve a crucial role in providing stability and strength to the tablet. They are essential in the process of tablet manufacturing, as they help hold the active pharmaceutical ingredients and excipients together, ensuring that the tablet maintains its integrity during handling, transportation, and storage. The presence of binders facilitates the formation of a solid mass when the powders are compressed, which is necessary for creating a cohesive tablet that can withstand the mechanical forces applied during production. Binders contribute to the physical properties of the tablet, such as hardness and friability, which are critical for ensuring that the tablets do not crumble easily. A strong and stable tablet is vital for proper drug delivery and patient compliance, as it ensures that the dosage form can be successfully swallowed and distributed within the body. While other options refer to different aspects of tablet formulation—such as enhancing absorption, increasing stability, or acting as disintegrants—these roles are distinctly served by other types of excipients. The primary function of a binder is indeed to impart strength and stability to the final tablet.