FPGEE NABP Practice Exam 2025 – Complete Prep Resource

The preferred technique for achieving a uniform preparation through mixing is geometric dilution. This method involves thoroughly mixing a small quantity of a drug or active ingredient with an appropriate amount of an inert substance or diluent in a stepwise fashion. The key aspect of geometric dilution is that the quantity of the active ingredient is gradually increased with an equal proportion of the diluent, ensuring that each increment is uniformly distributed throughout the mixture.

Geometric dilution is particularly effective in pharmacy practice when dealing with potent medications or low-dose drugs, as it minimizes the risk of any areas containing excessively high or low concentrations. By using this method, pharmacists can achieve a well-homogenized product that meets the required specifications for uniformity and efficacy.

On the other hand, volumetric dilution, periodic mixing, and sequential blending may not achieve the same level of uniformity as geometric dilution, especially when the volume of the active ingredient is small relative to the diluent. These methods can lead to variable distribution of the active component and may not ensure a consistent final product. Consequently, the use of geometric dilution is highly regarded for maintaining uniformity in pharmaceutical preparations.