FPGEE for National Association of Boards of Pharmacy (NABP) Practice Exam

What condition is characterized by an absolute decrease in bone tissue mass, leading to weakened and porous bones?

1. Arthritis

2. Osteoporosis

3. Osteomalacia

4. Rickets

The correct answer is: Osteoporosis

Osteoporosis is characterized by an absolute decrease in bone tissue mass, which results in weakened and porous bones, making them more susceptible to fractures. This condition occurs due to an imbalance in the process of bone remodeling, where bone resorption outpaces bone formation. As a result, the structural integrity of the bone is compromised, leading to an increase in the risk of breaks, often with minimal trauma. In contrast, other conditions listed do not fit this definition. Arthritis involves inflammation of the joints and does not primarily affect bone mass or density. Osteomalacia refers to the softening of the bones due to a deficiency of vitamin D or calcium, which leads to pain and deformity, but it is not specifically associated with a decrease in the quantity of bone tissue. Rickets is similar to osteomalacia but occurs in growing children and is due to vitamin D deficiency, affecting the growth and mineralization of bones. Therefore, osteoporosis is the condition that accurately reflects the characteristics provided in the question.